When it comes to treating stubborn fungal skin infections, Itraconazole remains one of the most prescribed antifungal medications. Its broad-spectrum activity and deep skin penetration make it highly effective for conditions like tinea corporis, tinea cruris, and candidiasis. Aingo Pharma offers a trusted formulation — Itraconazole Capsules 130 mg (Racole-SB 130) — designed with sustained-release technology for optimal absorption and long-lasting relief. In this blog, we’ll explore the ideal Itraconazole Dose For Skin Infections, how Aingo Pharma’s Racole-SB 130 stands out, and why it’s a preferred choice among healthcare professionals.
Itraconazole is a broad-spectrum antifungal medication in the triazole class, used to treat various fungal infections, including skin infections like dermatophytosis (ringworm, athlete’s foot, jock itch), pityriasis versicolor, and cutaneous candidiasis. It works by inhibiting ergosterol synthesis, a vital component of fungal cell membranes, leading to fungal cell death.
Aingo Pharma’s itraconazole capsules (130 mg and other strengths) are designed to deliver potent antifungal action with high bioavailability, making them a trusted choice for dermatologists and patients.
Itraconazole is highly effective for skin infections that are resistant to topical treatments or require systemic therapy. Aingo Pharma’s itraconazole formulations, available as capsules and oral solutions, ensure optimal absorption and tissue penetration, particularly in the skin and nails. Its long half-life and ability to persist in tissues make it ideal for treating chronic or recalcitrant fungal infections, such as those prevalent in India due to increasing antifungal resistance.
The composition of itraconazole, including its active and inactive ingredients, determines its efficacy, safety, and tolerability. Understanding these components helps patients and doctors assess potential allergies, drug interactions, and suitability for specific conditions. Aingo Pharma’s itraconazole is formulated with high-quality excipients to enhance stability and absorption, ensuring consistent therapeutic outcomes.
Aingo Pharma’s itraconazole capsules (e.g., 130 mg) may include:
In oral solutions, hydroxypropyl-β-cyclodextrin improves solubility but may cause osmotic diarrhea in some patients. Aingo Pharma ensures minimal use of excipients to reduce side effects while maintaining efficacy.
Itraconazole Dose For Skin Infections targets fungal cell membranes by inhibiting ergosterol synthesis, causing leakage and fungal death. Its active metabolite, hydroxyitraconazole, enhances antifungal activity. The drug’s lipophilic nature allows it to concentrate in skin (3–10 times higher than plasma) and nails, ensuring prolonged action even after treatment ends. Aingo Pharma’s super-bioavailable itraconazole (SB ITZ) achieves higher serum and skin concentrations, improving efficacy for resistant infections.
Itraconazole is indicated for:
Aingo Pharma’s itraconazole is particularly effective for recalcitrant dermatophytosis, addressing India’s growing challenge of antifungal resistance.
Itraconazole is generally safe but contraindicated in:
Aingo Pharma’s itraconazole, particularly its 130 mg SB ITZ capsules, offers superior bioavailability compared to conventional itraconazole (CITZ) brands like Sporanox. While active ingredients are identical, Aingo Pharma’s formulation uses advanced SUBA® technology to enhance absorption, reducing inter-patient variability and food dependency.
Generics contain the same active ingredient but may differ in excipients, affecting bioavailability. Aingo Pharma’s SB ITZ ensures bioequivalence with branded versions, with enhanced absorption for better outcomes.
Below is a table summarizing itraconazole dosages for skin infections, including Aingo Pharma’s SB ITZ:
Condition | Dosage (Conventional ITZ) | Dosage (Aingo Pharma SB ITZ) | Duration | Notes |
Tinea Corporis/Cruris | 100–200 mg once daily | 130 mg once daily | 2–4 weeks | Take with food |
Tinea Pedis | 100–200 mg once daily | 130 mg once daily | 2–4 weeks | Severe cases may require longer |
Pityriasis Versicolor | 200 mg once daily | 130 mg once daily | 5–7 days | Short course effective |
Cutaneous Candidiasis | 100–200 mg once daily | 130 mg once daily | 1–2 weeks | Adjust based on severity |
Source: Adapted from WebMD, Mayo Clinic, and Aingo Pharma guidelines
Aingo Pharma’s SB ITZ achieves higher serum and skin concentrations, allowing once-daily dosing compared to twice-daily for conventional itraconazole. Its long half-life (25–64 hours) supports convenient dosing schedules.
As a CYP3A4 inhibitor, itraconazole interacts with:
Aingo Pharma’s itraconazole, particularly its 130 mg Racole-SB 130 (SB ITZ) capsules, stands out due to:
Comparison Table: Aingo Pharma’s SB ITZ vs. Conventional ITZ vs. Alternatives
Feature | Aingo Pharma SB ITZ Racole-SB 130 | Conventional ITZ | Terbinafine | Fluconazole |
Bioavailability | ~80% | ~55% | High | High |
Food Requirement | With/without food | With food | With/without | With/without |
Dosing Frequency | Once daily | Once/twice daily | Once daily | Once daily |
Skin Penetration | High (3–10x plasma) | High | High | Moderate |
Spectrum | Broad (dermatophytes, yeasts, molds) | Broad | Dermatophytes | Yeasts |
Resistance Profile | Effective for resistant strains | Less effective | Increasing resistance | High resistance |
Cost | Cost-effective | Moderate | Moderate | Low |
Source: Adapted from Indian Dermatol Online J and microbiologyjournal.org
Itraconazole is a broad-spectrum antifungal medication used to treat various fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis. It inhibits the synthesis of ergosterol, a key component of fungal cell membranes. Example: Aingo Pharma’s Racole-SB 130 (Itraconazole Capsules 130 mg) is effective in treating systemic fungal infections and shows excellent absorption with sustained-release technology.
Each capsule of Itraconazole typically contains: – Itraconazole IP: 130 mg (as Pellets or SR form) – Excipients: q.s. – Dosage Form: Hard gelatin capsule Example: Aingo Pharma’s Racole-SB 130 contains 130 mg of pure Itraconazole in sustained-release form, ensuring better bioavailability and longer therapeutic effect.
Itraconazole capsules should be taken with food to improve absorption. The standard dosage is one capsule once or twice daily, depending on the type and severity of the infection. Always follow your doctor’s prescription. Example Usage:Racole-SB 130 by Aingo Pharma is typically recommended once daily after meals for optimal results in treating fungal infections.
Yes, some common side effects include: – Nausea and vomiting – Headache – Dizziness – Abdominal pain – Elevated liver enzymes Severe side effects (rare) may include liver toxicity or congestive heart failure in predisposed individuals. Example: With Racole-SB 130, most patients report good tolerance, but monitoring liver function is recommended during long-term use.
Itraconazole works by inhibiting the enzyme lanosterol 14α-demethylase, crucial for fungal cell membrane synthesis. This action disrupts the cell membrane and stops fungal growth. Example:Racole-SB 130 delivers this action effectively through its sustained-release mechanism, ensuring prolonged antifungal activity.
Itraconazole is effective against many systemic and superficial fungal infections but may not work against all fungal strains. Sensitivity testing or a doctor’s advice is crucial. Example: Aingo Pharma’s Racole-SB 130 is ideal for treating conditions like candidiasis, aspergillosis, and dermatophytosis.
Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children. Example:Racole-SB 130 comes in moisture-resistant blister packaging to ensure capsule integrity and efficacy.
Itraconazole interacts with several medications including antacids, proton pump inhibitors, and drugs metabolized by the CYP3A4 pathway. Always inform your doctor about all medicines you take. Example: While using Racole-SB 130, consult a physician before combining it with antibiotics, antivirals, or antihistamines.
Itraconazole is generally not recommended during pregnancy unless absolutely necessary. It may pass into breast milk, so caution is advised during breastfeeding. Example: Use of Racole-SB 130 in pregnant or lactating women should only be under strict medical supervision.
Most superficial fungal infections begin to respond within 7–10 days. Systemic infections may take weeks to months for full resolution. Example: Patients using Racole-SB 130 often notice improvement within a week for skin infections, but a full course must be completed.
Itraconazole is a cornerstone in treating fungal skin infections, offering broad-spectrum efficacy and excellent tissue penetration. Aingo Pharma’s Itraconazole Dose For Skin Infections, particularly its 130 mg super-bioavailable capsules, provides superior bioavailability, reduced dosing frequency, and consistent outcomes, making it the preferred choice for recalcitrant dermatophytosis. By combining advanced SUBA® technology with rigorous quality standards, Aingo Pharma ensures effective, safe, and accessible treatment for patients.
For more details on Aingo Pharma’s itraconazole, visit Aingo Pharma or consult your healthcare provider.