Itraconazole Dose For Skin Infections

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Itraconazole Dose For Skin Infections

itraconazole dose for skin infections

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Itraconazole Dose For Skin Infection : Aingo’s Pharma Itraconazole Capsules 130 mg (Racole-SB 130)

When it comes to treating stubborn fungal skin infections, Itraconazole remains one of the most prescribed antifungal medications. Its broad-spectrum activity and deep skin penetration make it highly effective for conditions like tinea corporis, tinea cruris, and candidiasis. Aingo Pharma offers a trusted formulation — Itraconazole Capsules 130 mg (Racole-SB 130) — designed with sustained-release technology for optimal absorption and long-lasting relief. In this blog, we’ll explore the ideal Itraconazole Dose For Skin Infections, how Aingo Pharma’s Racole-SB 130 stands out, and why it’s a preferred choice among healthcare professionals.

What Is Itraconazole?

Itraconazole is a broad-spectrum antifungal medication in the triazole class, used to treat various fungal infections, including skin infections like dermatophytosis (ringworm, athlete’s foot, jock itch), pityriasis versicolor, and cutaneous candidiasis. It works by inhibiting ergosterol synthesis, a vital component of fungal cell membranes, leading to fungal cell death.

Aingo Pharma’s itraconazole capsules (130 mg and other strengths) are designed to deliver potent antifungal action with high bioavailability, making them a trusted choice for dermatologists and patients.

Racole-SB 130

Overview of Itraconazole and Its Use

Itraconazole is highly effective for skin infections that are resistant to topical treatments or require systemic therapy. Aingo Pharma’s itraconazole formulations, available as capsules and oral solutions, ensure optimal absorption and tissue penetration, particularly in the skin and nails. Its long half-life and ability to persist in tissues make it ideal for treating chronic or recalcitrant fungal infections, such as those prevalent in India due to increasing antifungal resistance.

Why Understanding Composition Matters

The composition of itraconazole, including its active and inactive ingredients, determines its efficacy, safety, and tolerability. Understanding these components helps patients and doctors assess potential allergies, drug interactions, and suitability for specific conditions. Aingo Pharma’s itraconazole is formulated with high-quality excipients to enhance stability and absorption, ensuring consistent therapeutic outcomes.

Itraconazole Composition at a Glance

Active Ingredients in Itraconazole

  • Itraconazole: A triazole antifungal that inhibits lanosterol 14-α-demethylase, disrupting ergosterol synthesis in fungal cell membranes.

Inactive Ingredients & Their Purpose

Aingo Pharma’s itraconazole capsules (e.g., 130 mg) may include:

  • Hypromellose: Capsule shell for controlled release.
  • Polyethylene Glycol: Enhances solubility and absorption.
  • Microcrystalline Cellulose: Stabilizes the formulation.
  • Magnesium Stearate: Lubricant for manufacturing consistency.

In oral solutions, hydroxypropyl-β-cyclodextrin improves solubility but may cause osmotic diarrhea in some patients. Aingo Pharma ensures minimal use of excipients to reduce side effects while maintaining efficacy.

Strength and Dosage of Each Component

  • Capsules: Available in 100 mg, 130 mg (Aingo Pharma’s super-bioavailable formulation), and other strengths.
  • Oral Solution: 10 mg/mL. The active ingredient (itraconazole) is dosed based on the infection, while inactive ingredients support delivery without therapeutic effects.

How Itraconazole Works in the Body

Itraconazole Dose For Skin Infections targets fungal cell membranes by inhibiting ergosterol synthesis, causing leakage and fungal death. Its active metabolite, hydroxyitraconazole, enhances antifungal activity. The drug’s lipophilic nature allows it to concentrate in skin (3–10 times higher than plasma) and nails, ensuring prolonged action even after treatment ends. Aingo Pharma’s super-bioavailable itraconazole (SB ITZ) achieves higher serum and skin concentrations, improving efficacy for resistant infections.

Role of Each Ingredient in Treating Skin Infections

  • Itraconazole: Directly eliminates dermatophytes (e.g., Trichophyton, Microsporum) and yeasts (e.g., Candida, Malassezia).
  • Inactive Ingredients: Ensure effective delivery to infected tissues, with Aingo Pharma’s formulations optimized for minimal variability.

Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion

  • Absorption: Capsules require a full meal for optimal absorption (55% bioavailability); SB ITZ (e.g., Aingo Pharma’s 130 mg) offers higher bioavailability (~80%). Oral solutions are taken on an empty stomach.
  • Distribution: Highly protein-bound (>99%), concentrates in skin, nails, and fatty tissues. Negligible cerebrospinal fluid penetration limits CNS use.
  • Metabolism: Hepatic via CYP3A4, producing over 30 metabolites, including active hydroxyitraconazole.
  • Excretion: Primarily via bile and feces (54%), with <1% in urine. Skin concentrations persist for 2–4 weeks, nails up to 6 months.

What Conditions Does Itraconazole Treat?

Itraconazole is indicated for:

  • Skin Infections: Tinea corporis, tinea cruris, tinea pedis, pityriasis versicolor, cutaneous candidiasis.
  • Nail Infections: Onychomycosis.
  • Systemic Infections: Aspergillosis, blastomycosis, histoplasmosis.
  • Mucosal Infections: Oral/esophageal candidiasis (oral solution).

Aingo Pharma’s itraconazole is particularly effective for recalcitrant dermatophytosis, addressing India’s growing challenge of antifungal resistance.

Why Doctors Prescribe Itraconazole

  • Broad-spectrum activity against dermatophytes, yeasts, and molds.
  • High penetration into skin and nails.
  • Effective for both superficial and systemic infections.
  • Aingo Pharma’s SB ITZ offers superior bioavailability, reducing dosing frequency and improving patient compliance.

Safety & Warnings

Is the Composition of Itraconazole Safe for Everyone?

Itraconazole is generally safe but contraindicated in:

  • Hypersensitivity to azoles or excipients.
  • Congestive heart failure (risk of exacerbation).
  • Pregnancy (except for life-threatening infections).

Who Should Avoid This Medicine Based on Its Composition?

  • Patients with liver/kidney disease (requires monitoring).
  • Those on CYP3A4-metabolized drugs (e.g., statins, quinidine).
  • Women of childbearing age (use contraception during and 2 months post-treatment).

Possible Allergic Reactions to Certain Ingredients

  • Rare reactions (rash, hives, anaphylaxis) to itraconazole or cyclodextrin.
  • Cross-sensitivity with other azoles (e.g., fluconazole).

Comparison & Alternatives

Comparison with Other Brands: Is the Composition Different?

Aingo Pharma’s itraconazole, particularly its 130 mg SB ITZ capsules, offers superior bioavailability compared to conventional itraconazole (CITZ) brands like Sporanox. While active ingredients are identical, Aingo Pharma’s formulation uses advanced SUBA® technology to enhance absorption, reducing inter-patient variability and food dependency.

Alternative Medicines with Similar Composition

  • Fluconazole: Effective for candidiasis but less active against Aspergillus.
  • Terbinafine: Preferred for dermatophytosis; targets squalene epoxidase.
  • Voriconazole/Posaconazole: Broader spectrum for systemic infections.

Generic vs Branded Composition: What’s the Difference?

Generics contain the same active ingredient but may differ in excipients, affecting bioavailability. Aingo Pharma’s SB ITZ ensures bioequivalence with branded versions, with enhanced absorption for better outcomes.

Dosage & Administration

Recommended Dosage Based on Composition

Below is a table summarizing itraconazole dosages for skin infections, including Aingo Pharma’s SB ITZ:

ConditionDosage (Conventional ITZ)Dosage (Aingo Pharma SB ITZ)DurationNotes
Tinea Corporis/Cruris100–200 mg once daily130 mg once daily2–4 weeksTake with food
Tinea Pedis100–200 mg once daily130 mg once daily2–4 weeksSevere cases may require longer
Pityriasis Versicolor200 mg once daily130 mg once daily5–7 daysShort course effective
Cutaneous Candidiasis100–200 mg once daily130 mg once daily1–2 weeksAdjust based on severity

Source: Adapted from WebMD, Mayo Clinic, and Aingo Pharma guidelines

How Composition Affects Dosage Frequency

Aingo Pharma’s SB ITZ achieves higher serum and skin concentrations, allowing once-daily dosing compared to twice-daily for conventional itraconazole. Its long half-life (25–64 hours) supports convenient dosing schedules.

Special Considerations for Pediatric or Geriatric Use

  • Pediatric: 5 mg/kg/day (max 200 mg/day, oral solution preferred) for 2 weeks. Limited data for infants <6 months.
  • Geriatric: Dose adjustments may be needed due to increased risk of liver dysfunction or hearing loss. Monitor liver function tests (LFTs).

Side Effects & Interactions

Side Effects Linked to Key Ingredients

  • Itraconazole: Nausea, headache, diarrhea, rash, elevated LFTs (4%), rare hepatotoxicity or heart failure.
  • Cyclodextrin (oral solution): Osmotic diarrhea.

Drug Interactions Based on Active Composition

As a CYP3A4 inhibitor, itraconazole interacts with:

  • Contraindicated: Statins (lovastatin, simvastatin), quinidine, midazolam.
  • Monitored: Warfarin, digoxin, calcium channel blockers.
  • Acid Suppressants: Take itraconazole 2 hours apart from antacids/PPIs or with acidic drinks (e.g., cola).

Benefits of Itraconazole for Skin Infections

  • Broad-Spectrum Action: Targets dermatophytes, yeasts, and molds.
  • High Tissue Penetration: Concentrates in skin and nails for sustained efficacy.
  • Flexible Dosing: Once-daily SB ITZ reduces pill burden.
  • Proven for Resistant Infections: Effective against recalcitrant dermatophytosis.

Why Aingo Pharma’s Itraconazole Is the Best Choice

Aingo Pharma’s itraconazole, particularly its 130 mg Racole-SB 130 (SB ITZ) capsules, stands out due to:

  • Enhanced Bioavailability: Utilizes SUBA® technology, achieving ~80% bioavailability compared to ~55% for conventional itraconazole, ensuring higher drug levels in skin and serum.
  • Reduced Food Dependency: SB ITZ can be taken with or without food, unlike conventional capsules, improving patient compliance.
  • Lower Inter-Patient Variability: Minimizes absorption fluctuations, providing consistent therapeutic outcomes.
  • Optimized for Resistant Infections: Higher skin concentrations make it ideal for India’s epidemic of recalcitrant dermatophytosis.
  • Quality Manufacturing: Aingo Pharma adheres to stringent quality standards, ensuring reliable potency and safety.
  • Cost-Effective: Offers bioequivalent generics with superior performance, making treatment accessible without compromising efficacy.

How to Use Itraconazole Safely

  • Capsules: Take with a full meal (Aingo Pharma’s SB ITZ can be taken irrespective of meals).
  • Oral Solution: Take on an empty stomach, swish for several seconds before swallowing.
  • Complete the Course: Finish the prescribed duration to prevent recurrence or resistance.
  • Monitor Interactions: Inform your doctor of all medications to avoid CYP3A4 interactions.
  • Watch for Side Effects: Seek medical attention for liver issues (jaundice, dark urine) or heart failure symptoms (shortness of breath, swelling).

Comparison Table: Aingo Pharma’s SB ITZ vs. Conventional ITZ vs. Alternatives

FeatureAingo Pharma SB ITZ Racole-SB 130Conventional ITZTerbinafineFluconazole
Bioavailability~80%~55%HighHigh
Food RequirementWith/without foodWith foodWith/withoutWith/without
Dosing FrequencyOnce dailyOnce/twice dailyOnce dailyOnce daily
Skin PenetrationHigh (3–10x plasma)HighHighModerate
SpectrumBroad (dermatophytes, yeasts, molds)BroadDermatophytesYeasts
Resistance ProfileEffective for resistant strainsLess effectiveIncreasing resistanceHigh resistance
CostCost-effectiveModerateModerateLow

Source: Adapted from Indian Dermatol Online J and microbiologyjournal.org

itraconazole dose for skin infections

Frequently Asked Questions About Itraconazole Composition

What is Itraconazole used for?

Itraconazole is a broad-spectrum antifungal medication used to treat various fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis. It inhibits the synthesis of ergosterol, a key component of fungal cell membranes. Example: Aingo Pharma’s Racole-SB 130 (Itraconazole Capsules 130 mg) is effective in treating systemic fungal infections and shows excellent absorption with sustained-release technology.

What is the composition of Itraconazole Capsules?

Each capsule of Itraconazole typically contains: – Itraconazole IP: 130 mg (as Pellets or SR form) – Excipients: q.s. – Dosage Form: Hard gelatin capsule Example: Aingo Pharma’s Racole-SB 130 contains 130 mg of pure Itraconazole in sustained-release form, ensuring better bioavailability and longer therapeutic effect.

How should Itraconazole Capsules 130 mg be taken?

Itraconazole capsules should be taken with food to improve absorption. The standard dosage is one capsule once or twice daily, depending on the type and severity of the infection. Always follow your doctor’s prescription. Example Usage:Racole-SB 130 by Aingo Pharma is typically recommended once daily after meals for optimal results in treating fungal infections.

Are there any side effects of Itraconazole?

Yes, some common side effects include: – Nausea and vomiting – Headache – Dizziness – Abdominal pain – Elevated liver enzymes Severe side effects (rare) may include liver toxicity or congestive heart failure in predisposed individuals. Example: With Racole-SB 130, most patients report good tolerance, but monitoring liver function is recommended during long-term use.

How does Itraconazole work in the body?

Itraconazole works by inhibiting the enzyme lanosterol 14α-demethylase, crucial for fungal cell membrane synthesis. This action disrupts the cell membrane and stops fungal growth. Example:Racole-SB 130 delivers this action effectively through its sustained-release mechanism, ensuring prolonged antifungal activity.

Is Itraconazole 130 mg suitable for all types of fungal infections?

Itraconazole is effective against many systemic and superficial fungal infections but may not work against all fungal strains. Sensitivity testing or a doctor’s advice is crucial. Example: Aingo Pharma’s Racole-SB 130 is ideal for treating conditions like candidiasis, aspergillosis, and dermatophytosis.

What are the storage instructions for Itraconazole Capsules?

Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children. Example:Racole-SB 130 comes in moisture-resistant blister packaging to ensure capsule integrity and efficacy.

Can Itraconazole be taken with other medications?

Itraconazole interacts with several medications including antacids, proton pump inhibitors, and drugs metabolized by the CYP3A4 pathway. Always inform your doctor about all medicines you take. Example: While using Racole-SB 130, consult a physician before combining it with antibiotics, antivirals, or antihistamines.

Is Itraconazole safe during pregnancy and breastfeeding?

Itraconazole is generally not recommended during pregnancy unless absolutely necessary. It may pass into breast milk, so caution is advised during breastfeeding. Example: Use of Racole-SB 130 in pregnant or lactating women should only be under strict medical supervision.

How long does Itraconazole take to show results?

Most superficial fungal infections begin to respond within 7–10 days. Systemic infections may take weeks to months for full resolution. Example: Patients using Racole-SB 130 often notice improvement within a week for skin infections, but a full course must be completed.

Conclusion

Itraconazole is a cornerstone in treating fungal skin infections, offering broad-spectrum efficacy and excellent tissue penetration. Aingo Pharma’s Itraconazole Dose For Skin Infections, particularly its 130 mg super-bioavailable capsules, provides superior bioavailability, reduced dosing frequency, and consistent outcomes, making it the preferred choice for recalcitrant dermatophytosis. By combining advanced SUBA® technology with rigorous quality standards, Aingo Pharma ensures effective, safe, and accessible treatment for patients.

For more details on Aingo Pharma’s itraconazole, visit Aingo Pharma or consult your healthcare provider.

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